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KMID : 0384119930130020295
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 2 p.295 ~ p.302
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Clinical Significance and Incidence of Antineutrophil Cytoplasmic Antibody
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오정
최영진/강석진/김병기/심상인/김선무
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Abstract
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Antineutrophil cytoplasmic antibodies(ANCA) are autoantibodies against various antigens present in the cytoplasmic alpha granules of neutrophils and some monocytes detected by means of standard indirect immunofluorescent technique fixing the
neutrophils
with alcohol. They are characterized by their patterns of immunoreactivity; cytoplasmic pattern(CANCA), perinuclear pattern(P-ANCA), and granulocyte-specific antinuclear antibody(GSANA). ANCA have been known to be present in ANCA-associated
diseases
including Wegener's granulomatosis, microscopic polyarteritis nodosa, idiopathic crescentic glomerulonephtitis. But recently, other diseases rather than ANCA-associated diseases have been also reported to be positive for ANCA. We analyzed 191
patients
by indirect immunofluorescent microscopy to evaluate clinical significance and incidence of ANCA in ANCA-associated diseases and other diseases. ANCA were more commonly detected in females than males(1.9:1) and prevalent in the ages of 20-50
years(83.6%). ANCA positivie cases were lupus nephritis(70.6%), Wegener's granulomatosis, vasculitis, ulcerative colitis, and Behcet's syndrome revealed C-ANCA rather than P-ANCA.
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KEYWORD
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